Pinealon/PE-22-28/Selank
Ships fully reconstituted · no mixing, no powder, no bacteriostatic waterAdvanced Neuroprotective Blend
Triple neuroprotective blend for sleep, neuroregeneration, and calm focus.
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Frequently paired with
What it supports
- Supports circadian rhythm and sleep quality
- Neuroprotective and neuroregenerative effects
- Reduces anxiety without sedation
- Enhanced cognitive clarity
- Promotes neuroplasticity
- Stress resilience support
- Comprehensive brain health optimization
The details
- Administration
- Subcutaneous injection
- Format
- Pinealon + PE-22-28 + Selank combo, 5mL vial
- Typical dosing
- Per provider guidance, subcutaneous injection
- Best for
- Sleep repair, cognitive clarity, anxiety reduction
- Pairs well with
- DSIP, Epitalon
How it works
Signal
Pinealon/PE-22-28/Selank is given as a subcutaneous injection, often in cycles, on a provider-determined schedule.
Cellular response
Pinealon supports melatonin synthesis and circadian-rhythm regulation. PE-22-28 promotes neurogenesis and synaptic plasticity. Selank modulates GABA and serotonin for anxiolytic effects. Together they address sleep, neural repair, and cognitive performance.
Outcome
Over the following weeks most people notice deeper sleep first — sometimes vivid dreams as architecture normalizes (weeks 1–2), then waking up genuinely rested with the mental fog lifting and focus sharpening (weeks 2–4), then consistent high-quality sleep, better memory, and effortless emotional regulation (weeks 4–12). Many run periodic cycles.
Research highlights
Pinealon studied for circadian rhythm regulation
PE-22-28 research on neurogenesis and neuroprotection
Selank approved in Russia for anxiety and cognitive conditions
Complementary neuroprotective mechanisms
Research summaries are provided for educational context and are not a promise of results. Talk with your provider about what to expect.
Sources & references
Pinealon and circadian-gene regulation
Khavinson VK et al. Adv Gerontol. 2011.
View sourceBDNF and cognitive function (review)
Bekinschtein P et al. Nat Rev Neurosci. 2013.
View sourceSelank: anxiolytic and nootropic properties
Ershov FI et al. Regul Pept. 2014.
View source
Common questions
Important safety information
Pinealon/PE-22-28/Selank is available by prescription only and is dispensed after a licensed provider reviews your medical screening and determines it is appropriate for you. Compounded medications are prepared by a licensed U.S. pharmacy and are not FDA-approved products. Tell your provider about your full medical history and any medications you take.
- • Generally well tolerated
- • Possible injection site reactions
- • Should not be used during pregnancy or breastfeeding
- • Requires licensed provider supervision