Skip to main content
Ships fully reconstituted · no mixing, no powder, no bacteriostatic water
All peptides
Pinealon/PE-22-28/Selank
Cognitive

Pinealon/PE-22-28/Selank

Ships fully reconstituted · no mixing, no powder, no bacteriostatic water

Advanced Neuroprotective Blend

Triple neuroprotective blend for sleep, neuroregeneration, and calm focus.

Choose your supply

Extra 10% off your first order · use code WELCOME10 at checkout (stacks with the supply discount above).

Physician-reviewed · charged only after your prescription is approved
Free shipping over $350 · compounded in a U.S. pharmacy
We accept
Pay

Frequently paired with

Cognitive
Semax/Selank
Ships Reconstituted

Semax/Selank

Cognitive Clarity & Calm Focus

From

$229 / mo

View
Sleep
DSIP
Ships Reconstituted

DSIP

Deep Sleep Peptide

From

$175 / mo

View
Anti-Aging
Epitalon
Ships Reconstituted

Epitalon

The Longevity Peptide

From

$175 / mo

View

What it supports

  • Supports circadian rhythm and sleep quality
  • Neuroprotective and neuroregenerative effects
  • Reduces anxiety without sedation
  • Enhanced cognitive clarity
  • Promotes neuroplasticity
  • Stress resilience support
  • Comprehensive brain health optimization

The details

Administration
Subcutaneous injection
Format
Pinealon + PE-22-28 + Selank combo, 5mL vial
Typical dosing
Per provider guidance, subcutaneous injection
Best for
Sleep repair, cognitive clarity, anxiety reduction
Pairs well with
DSIP, Epitalon
Mechanism
Pinealon supports melatonin synthesis and circadian rhythm regulation. PE-22-28 promotes neurogenesis and synaptic plasticity. Selank modulates GABA and serotonin for anxiolytic effects. Together they address sleep, repair, and cognitive performance.

How it works

Signal

Pinealon/PE-22-28/Selank is given as a subcutaneous injection, often in cycles, on a provider-determined schedule.

Cellular response

Pinealon supports melatonin synthesis and circadian-rhythm regulation. PE-22-28 promotes neurogenesis and synaptic plasticity. Selank modulates GABA and serotonin for anxiolytic effects. Together they address sleep, neural repair, and cognitive performance.

Outcome

Over the following weeks most people notice deeper sleep first — sometimes vivid dreams as architecture normalizes (weeks 1–2), then waking up genuinely rested with the mental fog lifting and focus sharpening (weeks 2–4), then consistent high-quality sleep, better memory, and effortless emotional regulation (weeks 4–12). Many run periodic cycles.

Sources & references

  • Pinealon and circadian-gene regulation

    Khavinson VK et al. Adv Gerontol. 2011.

    View source

  • BDNF and cognitive function (review)

    Bekinschtein P et al. Nat Rev Neurosci. 2013.

    View source

  • Selank: anxiolytic and nootropic properties

    Ershov FI et al. Regul Pept. 2014.

    View source

  • Pinealon and cognitive function in elderly

    Bulletin of Experimental Biology and Medicine, 2012

    View source

  • Short peptides as bioregulators of aging

    Advances in Gerontology, 2015

    View source

  • Selank in attention and memory tasks

    Neuroscience and Behavioral Physiology, 2011

    View source

  • Peptide bioregulators in neuroprotection

    Biogerontology, 2018

    View source

Common questions

Important safety information

Pinealon/PE-22-28/Selank is available by prescription only and is dispensed after a licensed provider reviews your medical screening and determines it is appropriate for you. Compounded medications are prepared by a licensed U.S. pharmacy and are not FDA-approved products. Tell your provider about your full medical history and any medications you take.

  • • Generally well tolerated
  • • Possible injection site reactions
  • • Should not be used during pregnancy or breastfeeding
  • • Requires licensed provider supervision