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Ships fully reconstituted · no mixing, no powder, no bacteriostatic water
All peptides
MOTS-C
Energy

MOTS-C

Ships fully reconstituted · no mixing, no powder, no bacteriostatic water

The Mitochondrial Peptide

An exercise mimetic that boosts metabolism, insulin sensitivity, and cellular energy.

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Extra 10% off your first order · use code WELCOME10 at checkout (stacks with the supply discount above).

Physician-reviewed · charged only after your prescription is approved
Free shipping over $350 · compounded in a U.S. pharmacy
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Frequently paired with

EnergyWaitlist
AOD 9604
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AOD 9604

Pure Fat Burning Peptide

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$175 / mo

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EnergyWaitlist
AOD 9604/MOTS-C
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AOD 9604/MOTS-C

Fat Burning + Metabolic Reset

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$229 / mo

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Anti-Aging
NAD+
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NAD+

The Cellular Energy Coenzyme

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$175 / mo

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What it supports

  • Improves insulin sensitivity and glucose regulation
  • Enhances mitochondrial function and cellular energy
  • Acts as an exercise mimetic at the cellular level
  • Supports metabolic homeostasis
  • May reduce age-related metabolic decline
  • Promotes healthy body composition
  • Supports cardiovascular health markers

The details

Administration
Subcutaneous injection, morning
Format
5mg/mL, 5mL vial
Typical dosing
5-10mg subcutaneously 3-5 times weekly
Best for
Metabolism, exercise capacity, fat loss
Pairs well with
CJC-1295/Ipamorelin, NAD+, BPC-157
Mechanism
MOTS-C is encoded by mitochondrial DNA and activates AMPK signaling pathways, regulating glucose metabolism and fatty acid oxidation. It enhances cellular energy production by improving mitochondrial function and promotes metabolic flexibility, helping cells switch efficiently between fuel sources.

How it works

Signal

MOTS-c is given as a subcutaneous injection on a provider-determined schedule — often a few times a week.

Cellular response

MOTS-c is encoded by mitochondrial DNA and activates AMPK signaling, regulating glucose metabolism and fatty-acid oxidation. It improves mitochondrial function and metabolic flexibility, helping cells switch efficiently between fuel sources — much the way exercise does.

Outcome

Over the following weeks most people notice steadier energy and easier workout recovery first (weeks 1–2), then better endurance and fewer afternoon dips (weeks 2–4), then body-composition changes — tighter midsection, better tone (weeks 4–8). Diabetic patients should monitor blood glucose with their provider.

Sources & references

  • Exercise-induced regulator of physical decline

    Reynolds JC et al. Nat Commun. 2021;12:470.

    View source

  • Discovery: MOTS-c regulates metabolic homeostasis

    Lee C et al. Cell Metab. 2015;21(3):443–454.

    View source

  • MOTS-c expression and muscle aging

    D'Souza RF et al. Aging (Albany NY). 2020;12(6):5244–5258.

    View source

  • MOTS-c stimulates AMPK and improves glucose homeostasis

    Cell Metabolism, 2015

    View source

  • MOTS-c and skeletal muscle function with age

    Aging, 2020

    View source

  • MOTS-c in exercise adaptation and endurance

    Nature Communications, 2021

    View source

  • Mitochondrial peptides in cardiometabolic disease

    Trends in Endocrinology & Metabolism, 2018

    View source

Common questions

Important safety information

MOTS-C is available by prescription only and is dispensed after a licensed provider reviews your medical screening and determines it is appropriate for you. Compounded medications are prepared by a licensed U.S. pharmacy and are not FDA-approved products. Tell your provider about your full medical history and any medications you take.

  • • Generally well tolerated
  • • Possible injection site reactions
  • • Monitor blood glucose in diabetic patients
  • • Requires licensed provider supervision