MOTS-C
Ships fully reconstituted · no mixing, no powder, no bacteriostatic waterThe Mitochondrial Peptide
An exercise mimetic that boosts metabolism, insulin sensitivity, and cellular energy.
Choose your supply
Frequently paired with
What it supports
- Improves insulin sensitivity and glucose regulation
- Enhances mitochondrial function and cellular energy
- Acts as an exercise mimetic at the cellular level
- Supports metabolic homeostasis
- May reduce age-related metabolic decline
- Promotes healthy body composition
- Supports cardiovascular health markers
The details
- Administration
- Subcutaneous injection, morning
- Format
- 5mg/mL, 5mL vial
- Typical dosing
- 5-10mg subcutaneously 3-5 times weekly
- Best for
- Metabolism, exercise capacity, fat loss
- Pairs well with
- CJC-1295/Ipamorelin, NAD+, BPC-157
How it works
Signal
MOTS-c is given as a subcutaneous injection on a provider-determined schedule — often a few times a week.
Cellular response
MOTS-c is encoded by mitochondrial DNA and activates AMPK signaling, regulating glucose metabolism and fatty-acid oxidation. It improves mitochondrial function and metabolic flexibility, helping cells switch efficiently between fuel sources — much the way exercise does.
Outcome
Over the following weeks most people notice steadier energy and easier workout recovery first (weeks 1–2), then better endurance and fewer afternoon dips (weeks 2–4), then body-composition changes — tighter midsection, better tone (weeks 4–8). Diabetic patients should monitor blood glucose with their provider.
Research highlights
Studies show significant improvement in insulin sensitivity
Research demonstrates AMPK pathway activation similar to exercise
Trials showing reduced age-related metabolic dysfunction
Emerging data on longevity and healthspan extension
Research summaries are provided for educational context and are not a promise of results. Talk with your provider about what to expect.
Sources & references
Exercise-induced regulator of physical decline
Reynolds JC et al. Nat Commun. 2021;12:470.
View sourceDiscovery: MOTS-c regulates metabolic homeostasis
Lee C et al. Cell Metab. 2015;21(3):443–454.
View sourceMOTS-c expression and muscle aging
D'Souza RF et al. Aging (Albany NY). 2020;12(6):5244–5258.
View source
Common questions
Important safety information
MOTS-C is available by prescription only and is dispensed after a licensed provider reviews your medical screening and determines it is appropriate for you. Compounded medications are prepared by a licensed U.S. pharmacy and are not FDA-approved products. Tell your provider about your full medical history and any medications you take.
- • Generally well tolerated
- • Possible injection site reactions
- • Monitor blood glucose in diabetic patients
- • Requires licensed provider supervision